Lake City is a friendly, small regional hub in North Florida with affordable, quiet living, easy access to outdoor recreation (rivers, springs, and state parks), and a compact historic downtown—ideal for travel therapists who want pleasant, active downtime between shifts.
For weekend variety, Gainesville (University of Florida, arts, and larger medical amenities) and Jacksonville (major airport, beaches, and a bigger dining/nightlife scene) are both within about 75 miles, so you get peaceful workweeks with urban escapes nearby.