De Pere is a charming, walkable river city on the Fox River with a restored historic downtown, lively riverwalk, farmers markets, local breweries and plentiful parks — it feels like a cozy, active base rather than a place you’d dread staying for several weeks.
Nearby Green Bay (adjacent) brings pro‑sports, bigger dining and entertainment options (Lambeau Field events, museums), and Appleton (~25–30 miles) adds a larger arts/nightlife scene — all within easy driving distance.